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Background: Malaria is one of the world's deadly diseases caused by plasmodium, which is transmitted by Anopheles Sp mosquitoes and if not treated promptly, the patient will have severe complications and can die. Objective: To know the factors that influences the incidence of malaria in Midwifery students Mimika Poltekkes Kemenkes Jayapura Year 2018. Methods: Analytical survey with cross sectional study design conducted in April 2018 with a sample size of 120 people in total population. Data were obtained using questionnaire, analyzed using Chi-Square and multiple regression logistic with p-value significance <0,05. Result: Factors influencing the incidence of malaria in Mimika midwifery students were tribe (p-value 0,038, RP = 22,679; CI95% = 1,130- 6,354), activity at night (p-value <0,001, RP = 4,454; CI95% = 1,966-10,092), residence distance from breeding place (p-value 0,002, RP = 0,244; CI95% = 0,102- 0,588). Factors not affecting malaria incidence in midwifes student are poultry cage (p-value 0,053, RP = (P-value 0.229, RP = 0,567, CI95% = 0,257-1,254), distance of health service facility (p-value 0,746, RP = 1,240; CI95% = CI95% = 1,058-4,809) 0,556- 2,767), use of mosquito repellent (p-value 1,000, RP = 1.065; CI95% = 0.488-2,325). The dominant factors affecting the incidence of malaria in Mimika midwifery students are tribe, night activities, house distance with breeding place, where nighttime activities have a more dominant factor against malaria incidence in Mimika midwiferystudents. Keywords: ethnicity, behavioral factors,environmental factors, malaria incidence